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Bactrim is a synthetic combination antibacterial drug with two potent antibiotics as its key ingredients, sulfamethoxazole and trimethoprim, which act by inhibiting the production of folic acid in bacteria. The drug is prescribed for treating and preventing numerous bacterial infections, including UTIs, respiratory, ear and intestinal infections. The drug comes in oral tablets, which are typically taken q12h for 5-14 days.
What is Bactrim?
Bactrim is a fixed-combination medicinal product that contains two active substances: sulfamethoxazole and trimethoprim. The combination of these broad-spectrum antibiotics makes the drug effective against a large array of bacterial infections, including respiratory, intestinal, urine and middle ear infections. The drug is available in tablet form for oral administration, each containing 400 mg of sulfamethoxazole and 80 mg of trimethoprim. The inactive substances are: docusate sodium, sodium starch glycolate, sodium benzoate, pregelatinized starch and magnesium stearate.
When is Bactrim indicated?
Bactrim is indicated to treat UTIs, acute otitis media, acute worsening of chronic bronchitis in adults, traveler’s diarrhea in adults and shigellosis. The drug is also approved for the treatment and prevention of Pneumocystis carinii pneumonia in immunosuppressed patients. It can be prescribed to children over two months old to treat UTIS, shigellosis and ear infections.
How to take Bactrim?
Bactrim average dose that is likely to work for most infections in adults is 2 tablets twice daily for 10-14 days. The same dosage in prescribed to treat shigellosis and traveler’s diarrhea in adults, but the length of treatment constitutes 5 days. The pediatric dosage for the treatment of UTIs, acute otitis media, Pneumocystis carinii pneumonia and shigellosis is determined by weight and usually is 40mg/kg of sulfamethoxazole and 8 mg/kg of trimethoprim per day in two divided doses for 5 days in case of shigellosis and for 10 days for other infections.
What are Bactrim side effects?
Bactrim can cause gastrointestinal disturbances as vomiting, nausea, loss of appetite and allergic skin reactions as rash and itching. In order to prevent the development of more severe adverse effects seek immediate medical attention at the first sign of allergy. Less common side effects include diarrhea, decreased urination and shortness of breath.
When is Bactrim contraindicated?
Bactrim is contraindicated to patients with megaloblastic anemia due to folate deficiency, patients with a history of drug-induced immune thrombocytopenia and at individual intolerance to any of its ingredients. It shouldn’t be administered to children under two months of age and patients with marked hepatic damage or severe renal insufficiency.