Macrobid is an antibacterial antibiotic specific to urinary infections. It has Nitrofurantonin as main ingredient, which is active against E.coli and Staphylococcus saprophyticus. It kills bacteria by damaging their DNA. The antibiotic is available in capsules with 50 mg strength, typically taken 4 times a day for 7 days. The drug’s intake with food improves its absorption by 45%.
What is Macrobid?
Macrobid is an antimicrobial agent of the nitrofuran class, specific for urinary infections treatment. In comparison with other antibiotics it works in a unique way. It destroys certain molecules and proteins within bacterial cells, resulting in stopping bacteria from making essential cell components, including DNA, protein and cell walls. The antibiotic comes as capsules containing the equivalent of 100 mg Nitrofurantoin in the form of 75 mg Nitrofurantoin monohydrate and 25 mg of Nitrofurantoin macrocrystals.
When is Macrobid indicated?
Macrobid is indicated only for treating or preventing bladder infections, in particular those, incited by Staphylococcus saprophyticus, Shigella and Escherichia coli bacteria. It is generally prescribed for acute uncomplicated UTIs, including acute cystitis or urethritis. The antibiotic is not effective for treating kidney infections, such pyelonephritis or perinephric abscess and is not approved for use in patients under 12.
How to take Macrobid?
Macrobid dosage is universal for all patients aged over 12. It is generally administered in a dose of 100 mg twice daily for 7 days. Capsules should be taken with food, as this helps the medicine to be better absorbed by the body. Doses should be taken at evenly spaced intervals to assure the most benefit of this medication. The antibiotic must be taken continuously until the full course is completed, and shouldn’t be stopped earlier even if all clinical signs and symptoms subsided.
When is Macrobid contraindicated?
Macrobid is contraindicated to patients with known allergies to Nitrofurantoin as well as to patients with a history of hepatic dysfunction or cholestatic jaundice. It shouldn’t be used in people with oliguria, anuria or significant renal impairment. It is contraindicated to women at 38-42 weeks of pregnancy, during labor and delivery. Avoid alcohol intake while on this drug.
What are Macrobid side effects?
Macrobid may cause headache, nausea and flatulence, which are typically mild and require no medical attention. In rare cases it may provoke some serious effects, including signs of lung or liver problems, severe diarrhea, indigestion, constipation, vomiting, fever, dizziness, amblyopia, hair loss and allergic reactions. However, these effects are generally rare and appear in less than 1% of patients.